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T cells reactive with the NC16A domain of BP180 are present in vulval lichen sclerosus and lichen planus.

Abstract:

BACKGROUND: Lichen sclerosus (LS) is a chronic inflammatory skin condition. The recent demonstration of circulating autoantibodies to extracellular matrix protein 1 and to basement membrane zone (BMZ) components, chiefly BP180, suggests that autoimmunity to these components might contribute to pathogenesis. However, there is no binding of autoantibodies in vivo and as LS is characterized by a lymphocytic infiltrate, it seems likely that LS is mediated, in part, by antigen-specific lymphocytes...

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Publication status:
Published

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Authors


Groves, RW More by this author
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Journal:
Journal of the European Academy of Dermatology and Venereology : JEADV
Volume:
24
Issue:
2
Pages:
186-190
Publication date:
2010-02-05
DOI:
EISSN:
1468-3083
ISSN:
0926-9959
URN:
uuid:a68872cd-8831-435c-9d41-db650a81c8ef
Source identifiers:
50074
Local pid:
pubs:50074

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