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Journal article

Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids.

Abstract:
γ-Butyrobetaine hydroxylase (BBOX) is a 2-oxoglutarate dependent oxygenase that catalyzes the final hydroxylation step in the biosynthesis of carnitine. BBOX was shown to catalyze the oxidative desymmetrization of achiral N,N-dialkyl piperidine-4-carboxylates to give products with two or three stereogenic centers.
Publication status:
Published

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Publisher copy:
10.1002/anie.201406125

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Journal:
Angewandte Chemie (International ed. in English) More from this journal
Volume:
53
Issue:
41
Pages:
10925-10927
Publication date:
2014-10-01
DOI:
EISSN:
1521-3773
ISSN:
1433-7851
Language:
English
Keywords:
Pubs id:
pubs:482487
UUID:
uuid:a6872012-3338-4140-a2ea-c1c8a640f293
Local pid:
pubs:482487
Source identifiers:
482487
Deposit date:
2014-09-10

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