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Journal article

TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway

Abstract:

Preventing virally induced liver disease begins with an understanding of the host factors that define susceptibility to infection. Hepatitis C virus (HCV) is a global health issue, with an estimated 170 million infected individuals at risk of developing liver disease including fibrosis and hepatocellular carcinoma. The liver is the major reservoir supporting HCV replication and this hepatocellular tropism is defined by HCV engagement of cellular entry receptors. Hepatocytes are polarized in v...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1099/jgv.0.000689

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
Microbiology Society Publisher's website
Journal:
Journal of General Virology Journal website
Volume:
98
Issue:
3
Pages:
405-412
Publication date:
2017-03-01
Acceptance date:
2016-12-15
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Source identifiers:
673502
Language:
English
Keywords:
Pubs id:
pubs:673502
UUID:
uuid:a680ece5-3baf-4a9e-8aef-b467771d14f0
Local pid:
pubs:673502
Deposit date:
2017-01-29

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