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Journal article

TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway.

Abstract:

Preventing viral induced liver disease begins with an understanding 1 of the host factors that define susceptibility to infection. Hepatitis C Virus (HCV) is a global health issue with an estimated 170 million infected individuals at risk of developing liver disease including fibrosis and hepatocellular carcinoma. The liver is the major reservoir supporting HCV replication and this hepatocellular tropism is defined by HCV engagement of cellular entry receptors. Hepatocytes are polarised in vi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscipt

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Publisher copy:
10.1099/jgv.0.000689

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Department:
Oxford, MSD, NDM, Target Discovery Institute
Role:
Author
Publisher:
Microbiology Society Publisher's website
Journal:
Journal of General Virology Journal website
Volume:
98
Pages:
405-412
Publication date:
2017-03-05
Acceptance date:
2016-12-15
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
Pubs id:
pubs:673502
URN:
uri:a680ece5-3baf-4a9e-8aef-b467771d14f0
UUID:
uuid:a680ece5-3baf-4a9e-8aef-b467771d14f0
Local pid:
pubs:673502
Language:
English

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