Centrioles organise centrosomes and cilia and these organelles have an important role in many cell processes. In flies, the centriole protein Ana1 is required for the assembly of functional centrosomes and cilia. It has recently been shown that Cep135/Bld10 initially recruits Ana1 to newly formed centrioles and Ana1 then recruits Asl/Cep152 to promote the conversion of these centrioles to centrosomes. Here we show that ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibl...Expand abstract
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Copyright © 2016. Published by The Company of Biologists Ltd
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