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Investigating the induction of vaccine-induced Th17 and regulatory T cells in healthy, Mycobacterium bovis BCG-immunized adults vaccinated with a new tuberculosis vaccine, MVA85A.

Abstract:

Tuberculosis (TB) remains a threat to global health. While advances in diagnostics and treatment are crucial to the containment of the epidemic, it is likely that elimination of the disease can only be achieved through vaccination. Vaccine-induced protection from Mycobacterium tuberculosis is dependent, at least in part, on a robust Th1 response, yet little is known of the ability of TB vaccines to induce other T-cell subsets which may influence vaccine efficacy. Interleukin-17A (IL-17A) is a...

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Publication status:
Published

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Publisher copy:
10.1128/cvi.00047-10

Authors


de Cassan, SC More by this author
Pathan, AA More by this author
Sander, CR More by this author
Minassian, A More by this author
Rowland, R More by this author
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Journal:
Clinical and vaccine immunology : CVI
Volume:
17
Issue:
7
Pages:
1066-1073
Publication date:
2010-07-05
DOI:
EISSN:
1556-679X
ISSN:
1556-6811
URN:
uuid:a66bfa8f-1852-4a21-a423-9ba0c8ccc2f1
Source identifiers:
54776
Local pid:
pubs:54776

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