- Abstract:
-
The ability of four central cholinomimetics to reverse a scopolamine-induced spatial memory impairment or to improve visual recognition memory in primates was examined. Physostigmine (0.04-0.08 mg/kg IM) fully reversed the effects of scopolamine (0.03 mg/kg). Coadministration of pilocarpine (3.0-5.0 mg/kg) caused partial reversal of the scopolamine impairment after intermediate or long retention intervals (10 or 20 s). Treatment with arecoline (0.1-1.8 mg/kg) or nicotine (1.0-2.0 mg/kg) gener...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1007/bf00442806
-
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- Journal:
- Psychopharmacology
- Volume:
- 99
- Issue:
- 2
- Pages:
- 189-195
- Publication date:
- 1989
- DOI:
- EISSN:
-
1432-2072
- ISSN:
-
0033-3158
- URN:
-
uuid:a66a92f2-5368-4bae-b1e5-8badcf9ac28b
- Source identifiers:
-
1111
- Local pid:
- pubs:1111
- Language:
- English
- Keywords:
- Copyright date:
- 1989
Journal article
Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects.
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