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Journal article

Comparison of the effects of four cholinomimetic agents on cognition in primates following disruption by scopolamine or by lists of objects.

Abstract:

The ability of four central cholinomimetics to reverse a scopolamine-induced spatial memory impairment or to improve visual recognition memory in primates was examined. Physostigmine (0.04-0.08 mg/kg IM) fully reversed the effects of scopolamine (0.03 mg/kg). Coadministration of pilocarpine (3.0-5.0 mg/kg) caused partial reversal of the scopolamine impairment after intermediate or long retention intervals (10 or 20 s). Treatment with arecoline (0.1-1.8 mg/kg) or nicotine (1.0-2.0 mg/kg) gener...

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Publication status:
Published

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Publisher copy:
10.1007/bf00442806

Authors


Rupniak, NM More by this author
Steventon, MJ More by this author
Jennings, CA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
Psychopharmacology
Volume:
99
Issue:
2
Pages:
189-195
Publication date:
1989
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
URN:
uuid:a66a92f2-5368-4bae-b1e5-8badcf9ac28b
Source identifiers:
1111
Local pid:
pubs:1111

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