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Hexose permeation pathways in Plasmodium falciparum-infected erythrocytes

Abstract:

Plasmodium falciparum requires glucose as its energy source to multiply within erythrocytes but is separated from plasma by multiple membrane systems. The mechanism of delivery of substrates such as glucose to intraerythrocytic parasites is unclear. We have developed a system for robust functional expression in Xenopus oocytes of the P. falciparum asexual stage hexose permease, PfHT1, and have analyzed substrate specificities of PfHT1. We show that PfHT1 (a high-affinity glucose transporter, ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.170153097

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Tropical Medicine, Thailand/Laos MOP
Burchmore, RJ More by this author
Krishna, S More by this author
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
97
Issue:
18
Pages:
9931–9936
Publication date:
2000-08-29
Acceptance date:
2000-06-21
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a66806fb-2b3f-487a-8507-0408b730cd79
Source identifiers:
619163
Local pid:
pubs:619163
Keywords:

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