- Abstract:
-
Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the prediabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng0893-404
-
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- Journal:
- Nature genetics
- Volume:
- 4
- Issue:
- 4
- Pages:
- 404-409
- Publication date:
- 1993-08-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:a6606335-1142-4b00-b72d-7c854e22a909
- Source identifiers:
-
6535
- Local pid:
- pubs:6535
- Language:
- English
- Keywords:
- Copyright date:
- 1993
Journal article
Polygenic control of autoimmune diabetes in nonobese diabetic mice.
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