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Journal article

Polygenic control of autoimmune diabetes in nonobese diabetic mice.

Abstract:

Partial exclusion mapping of the nonobese (NOD) diabetic mouse genome has shown linkage of diabetes to at least five different chromosomes. We have now excluded almost all of the genome for the presence of susceptibility genes with fully recessive effects and have obtained evidence of linkage of ten distinct loci to diabetes or the prediabetic lesion, insulitis, indicative of a polygenic mode of inheritance. The relative importance of these loci and their interactions have been assessed using...

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Publication status:
Published

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Publisher copy:
10.1038/ng0893-404

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Journal:
Nature genetics
Volume:
4
Issue:
4
Pages:
404-409
Publication date:
1993-08-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:a6606335-1142-4b00-b72d-7c854e22a909
Source identifiers:
6535
Local pid:
pubs:6535

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