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Journal article

Subtle changes in the ageing human brain.

Abstract:

Subtle changes in the human brain constitute a third element in addition to plaques and tangles as markers of vulnerability to Alzheimer's disease (AD). Neurofibrillary tangle (NFT) distribution shows the closest relationship to the severity of dementia. Two features of the distribution (regional selectivity and columnar clustering) provide clues about the structural changes due to normal ageing that may precede tangle formation. It is hypothesized that the columnar organization of the cortex...

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Publisher copy:
10.1177/026010600601800303

Authors


Chance, SA More by this author
Journal:
Nutrition and health
Volume:
18
Issue:
3
Pages:
217-224
Publication date:
2006
DOI:
EISSN:
2047-945X
ISSN:
0260-1060
URN:
uuid:a6485ab9-c96e-4516-8c67-15482261c498
Source identifiers:
243002
Local pid:
pubs:243002

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