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Distribution and dynamics of adamantanes in a lipid bilayer.

Abstract:

The adamantanes are a class of compounds that have found use in the treatment of influenza A and Parkinson's disease, among others. The mode of action for influenza A is based on the adamantanes' interaction with the transmembrane M2 channel, whereas the treatment of Parkinson's disease is thought to relate to a channel block of N-methyl-D-aspartate receptors. An understanding of how these compounds interact with the lipid bilayer is thus of great interest. We used molecular-dynamics simulati...

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Publication status:
Published

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Publisher copy:
10.1529/biophysj.108.139477

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Biophysical journal
Volume:
95
Issue:
12
Pages:
5627-5636
Publication date:
2008-12-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:a6117415-1ff1-4480-86f0-cc16d5d072e4
Source identifiers:
99982
Local pid:
pubs:99982

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