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Journal article

New perspectives on the ligands and function of the killer cell immunoglobulin-like receptor KIR3DL2 in health and disease.

Abstract:

KIR3DL2/CD158k/p140 is a three domain killer cell immunoglobulin-like receptor incorporating cytoplasmic immunoreceptor tyrosine inhibitory motifs, expressed as a disulphide-bonded dimer. KIR3DL2 is a framework gene within the KIR locus and is highly polymorphic, with 62 allelic variants possibly coding for protein reported. KIR3DL2 binds to HLA-A3 and -A11 in a peptide-dependent fashion and to B27 free heavy chain forms. In addition, KIR3DL2 can also function as an innate immune receptor for...

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Publisher copy:
10.3389/fimmu.2012.00339

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, Experimental Medicine Division
Role:
Author
Journal:
Frontiers in immunology
Volume:
3
Issue:
NOV
Pages:
339
Publication date:
2012-01-01
DOI:
EISSN:
1664-3224
URN:
uuid:a60ccf0b-3af1-4a5f-b604-3a8a92f25b46
Source identifiers:
363822
Local pid:
pubs:363822

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