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Journal article

Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype.

Abstract:

Bacteria adapt to environmental changes through high-frequency switches in expression of specific phenotypes. Localized hypermutation mediated by simple sequence repeats is an important mechanism of such phase variation (PV) in Neisseria meningitidis. Loss or gain of nucleotides in a poly(C) tract located in the reading frame results in switches in expression of lgtG and determines whether a glucose or a phosphoethanolamine (PEtn) is added at a specific position in the inner core lipopolysacc...

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Publication status:
Published

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Publisher copy:
10.1128/iai.00395-08

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Journal:
Infection and immunity
Volume:
76
Issue:
11
Pages:
5038-5048
Publication date:
2008-11-05
DOI:
EISSN:
1098-5522
ISSN:
0019-9567
URN:
uuid:a5dfc5c5-c975-4f4f-821a-2f9b068003a0
Source identifiers:
115589
Local pid:
pubs:115589

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