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Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest.

Abstract:

Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance. A human COMT polymorphism (Val(158)Met) alters enzyme activity and is associated with both the activation and functional connectivity of the PFC during task performance, particularly working memory. Here, we used functional magnetic resonance imaging and a data-driven, independent components analysis (ICA) approach to compare resting state fun...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Role:
Author
Journal:
NeuroImage
Volume:
68
Pages:
49-54
Publication date:
2013-03-05
DOI:
EISSN:
1095-9572
ISSN:
1053-8119
URN:
uuid:a5dbcc2f-5d3e-4a21-beea-7fa7aa0b8b68
Source identifiers:
367687
Local pid:
pubs:367687

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