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FUS/TLS is a novel mediator of androgen-dependent cell-cycle progression and prostate cancer growth.

Abstract:

Progression of prostate cancer is highly dependent upon the androgen receptor pathway, such that knowledge of androgen-regulated proteins is vital to understand and combat this disease. Using a proteomic screen, we found the RNA-binding protein FUS/TLS (Fused in Ewing's Sarcoma/Translocated in Liposarcoma) to be downregulated in response to androgen. FUS has recently been shown to be recruited by noncoding RNAs to the regulatory regions of target genes such as cyclin D1, in which it represses...

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Publication status:
Published

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Authors


Brooke, GN More by this author
Culley, RL More by this author
Gaughan, L More by this author
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Journal:
Cancer research
Volume:
71
Issue:
3
Pages:
914-924
Publication date:
2011-02-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:a5d97eac-66eb-4b1f-a717-745dd96f17d7
Source identifiers:
228738
Local pid:
pubs:228738

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