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The effects of vascular and nonvascular adverse events and of extended-release niacin with laropiprant on health and healthcare costs

Abstract:
Background: Extended-release niacin with laropiprant did not significantly reduce the risk of major vascular events and increased the risk of serious adverse events in HPS2-THRIVE but its net effects on health and healthcare costs are unknown. Methods and Results: 25,673 participants aged 50 to 80 years with prior vascular disease were randomized to 2g of extended-release niacin with 40mg of laropiprant daily versus matching placebo, in addition to effec... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1161/CIRCOUTCOMES.115.002592

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health
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More from this funder
Funding agency for:
Hopewell, J
Medical Research Council More from this funder
British Heart Foundation More from this funder
Cancer Research UK More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Circulation: Cardiovascular Quality and Outcomes Journal website
Volume:
2016
Issue:
9
Pages:
348-354
Publication date:
2016-07-12
Acceptance date:
2016-04-20
DOI:
EISSN:
1941-7705
ISSN:
1941-7713
URN:
uuid:a5d7691b-9ac0-4da0-9c42-72f528adf815
Source identifiers:
619251
Local pid:
pubs:619251

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