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Journal article

Coefficient of failure: a methodology for examining longitudinal beta-cell function in Type 2 diabetes.

Abstract:

AIMS: We describe a new method, the determination of the coefficient of failure, which allows the assessment of beta-cell failure from any index of glycaemia. Previous methods using glycaemic thresholds and calculating time-to-failure have systematic deficiencies relating to bias, reproducibility and statistical power. Analyses using threshold methodologies and conventional survival analysis have an intrinsic disadvantage in that they use categorical data and thus make no allowance for near-f...

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Publication status:
Published

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Authors


Wallace, TM More by this author
Matthews, DR More by this author
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Volume:
19
Issue:
6
Pages:
465-469
Publication date:
2002-06-05
DOI:
EISSN:
1464-5491
ISSN:
0742-3071
URN:
uuid:a5d6c87c-f51c-42ac-b4b5-8b2b930fc858
Source identifiers:
72809
Local pid:
pubs:72809

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