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The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies

Abstract:

Tumor cells exploit their microenvironment by growth factors and cytokines such as vascular endothelial growth factor (VEGF) to stimulate abnormal vessel formation that is leaky and tortuous, causing irregular blood flow. The combination of poor perfusion, raised interstitial fluid pressure and areas of vascular collapse leads to hypoxia within tumor. The latter activates factors such as hypoxia inducible factor 1 (HIF-1) that serve to make cancer cells more aggressive and also markedly influ...

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Publisher copy:
10.1007/s10555-012-9394-4

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
Cancer and Metastasis Reviews
Volume:
31
Issue:
3-4
Pages:
823-842
Publication date:
2012-12-05
DOI:
EISSN:
1573-7233
ISSN:
0167-7659
URN:
uuid:a5cb2903-54b6-4dd4-83bc-aef058fd8854
Source identifiers:
359792
Local pid:
pubs:359792

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