Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses.

Journal article

PKC- is central to T-helper (Th) 2 cell differentiation and effector function; however, its importance for antiviral effector, and in particular memory CD8(+) T cell responses, remains unclear. We have investigated the role of PKC- during in vivo and in vitro responses against influenza virus, lymphocytic choriomeningitis virus, vaccinia virus, and replication-deficient virus-like particles. In the absence of PKC-, antiviral CD8(+) T cells presented an unresponsive phenotype in vitro, which c...

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Authors: Marsland, B; Nembrini, C; Schmitz, N; Abel, B; Krautwald, S

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 102
• Issue: 40
• Pages: 14374-14379
• Publication date: 2005-10-01
• DOI: 10.1073/pnas.0506250102
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Immunologic Memory; Virion; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Protein Kinase C; Viruses; Flow Cytometry; Vaccinia; Mice, Inbred C57BL; Mice; Animals; Cell Proliferation; CD8-Positive T-Lymphocytes; Cytotoxicity Tests, Immunologic; RNA Virus Infections