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Journal article

Innate signals compensate for the absence of PKC-{theta} during in vivo CD8(+) T cell effector and memory responses.

Abstract:

PKC- is central to T-helper (Th) 2 cell differentiation and effector function; however, its importance for antiviral effector, and in particular memory CD8(+) T cell responses, remains unclear. We have investigated the role of PKC- during in vivo and in vitro responses against influenza virus, lymphocytic choriomeningitis virus, vaccinia virus, and replication-deficient virus-like particles. In the absence of PKC-, antiviral CD8(+) T cells presented an unresponsive phenotype in vitro, which c...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0506250102

Authors


Marsland, BJ More by this author
Nembrini, C More by this author
Schmitz, N More by this author
Krautwald, S More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
40
Pages:
14374-14379
Publication date:
2005-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a5c337c3-afcd-4977-8d4f-28d898ca1fb4
Source identifiers:
469729
Local pid:
pubs:469729

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