Post-streptococcal opsoclonus-myoclonus syndrome associated with anti-neuroleukin antibodies.

Journal article

BACKGROUND: Adult opsoclonus-myoclonus (OM), a disorder of eye movements accompanied by myoclonus affecting the trunk, limbs, or head, is commonly associated with an underlying malignancy or precipitated by viral infection. METHODS: We present the first two reports of post-streptococcal OM associated with antibodies against a 56 kDa protein. Two young girls presented with opsoclonus and myoclonus following a febrile illness and pharyngitis. Protein purification techniques were employed. Amin...

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Authors: Candler, P; Dale, R; Griffin, S; Church, A; Wait, R

• Publication status: Published
• Journal: Journal of neurology, neurosurgery, and psychiatry
• Volume: 77
• Issue: 4
• Pages: 507-512
• Publication date: 2006-04-01
• DOI: 10.1136/jnnp.2005.078105
• EISSN: 1468-330X
• ISSN: 0022-3050
• Language: English
• Keywords: DNA Primers; Antigens, Bacterial; Glucose-6-Phosphate Isomerase; Humans; Electrophoresis, Polyacrylamide Gel; RNA, Messenger; Autoantigens; Immunohistochemistry; Female; Chromatography, Ion Exchange; Reverse Transcriptase Polymerase Chain Reaction; Autoantibodies; Immunoblotting; Paraneoplastic Syndromes, Nervous System; Cell Membrane; Bacterial Outer Membrane Proteins; Adolescent; Streptococcal Infections; DNA, Complementary