Protein homoeostasis is a fundamental requirement for all living cells in order to survive in a dynamic surrounding. Proper levels of AIRAPL (arsenite-inducible RNA-associated protein-like protein) (ZFAND2B) are required in order to maintain cellular folding capacity in metazoans, and functional impairment of AIRAPL results in acceleration of aging and protein aggregation. However, the cellular roles of AIRAPL in this process are not known. In the present paper, we report that AIRAPL binds an...Expand abstract
- Publisher copy:
- Copyright date:
Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.
If you are the owner of this record, you can report an update to it here: Report update to this record