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Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells.

Abstract:

Permeabilized patch whole-cell voltage clamp methods were used to investigate the effects of isoprenaline (ISO) on total delayed rectifier potassium current, iK, in rabbit sino-atrial (SA) node pacemaker cells; total iK is composed of the rapidly activating iKr and the slowly activating iKs, but predominantly iKr in this species. ISO (20 nM) increased the amplitude of total iK and caused a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the pre...

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Publication status:
Published

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Publisher copy:
10.1017/s0958067000019151

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology, BHF Centre of Research Excellence
Role:
Author
Journal:
Experimental physiology
Volume:
85
Issue:
1
Pages:
27-35
Publication date:
2000-01-05
DOI:
EISSN:
1469-445X
ISSN:
0958-0670
URN:
uuid:a5b4acaf-99ba-43e2-9535-ac2331300e53
Source identifiers:
106427
Local pid:
pubs:106427

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