Ibotenate-induced total septal lesions reduce resistance to extinction but spare the partial reinforcement extinction effect in the rat.

Journal article

Rats were given sham operations, vehicle injections, or injections of the axon-sparing excitotoxin ibotenic acid into the septum. In Experiment 1, behavioural testing commenced 16 days after the operation; in Experiment 2 behavioural testing commenced following testing on another task, 31 days after the operation. The rats were trained to run in an alley for food reward given on every trial (Continuous Reinforcement, CR) or on a random fifty percent of trials (Partial Reinforcement, PR) and t...

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Authors: Coffey, P; Feldon, J; Mitchell, S; Sinden, J; Gray, J

• Publication status: Published
• Journal: Experimental brain research
• Volume: 77
• Issue: 1
• Pages: 140-152
• Publication date: 1989-01-01
• DOI: 10.1007/bf00250576
• EISSN: 1432-1106
• ISSN: 0014-4819
• Language: English
• Keywords: Septal Nuclei; Ibotenic Acid; Serotonin; Oxazoles; Rats; Frontal Lobe; Catecholamines; Hippocampus; Rats, Inbred Strains; Learning; Animals; Reinforcement (Psychology)