Journal article
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming.
- Abstract:
-
Erasure of epigenetic memory is required to convert somatic cells towards pluripotency. Reactivation of the inactive X chromosome (Xi) has been used to model epigenetic reprogramming in mouse, but human studies are hampered by Xi epigenetic instability and difficulties in tracking partially reprogrammed iPSCs. Here we use cell fusion to examine the earliest events in the reprogramming-induced Xi reactivation of human female fibroblasts. We show that a rapid and widespread loss of Xi-associate...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 1.8MB, Terms of use)
-
- Publisher copy:
- 10.1038/ncomms12354
Authors
Funding
Bibliographic Details
- Publisher:
- Nature Publishing Group
- Journal:
- Nature Communications More from this journal
- Publication date:
- 2016-08-10
- Acceptance date:
- 2016-06-24
- DOI:
- ISSN:
-
2041-1723
- Pmid:
-
27507283
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:638533
- UUID:
-
uuid:a58f7f12-7de2-4a11-a269-e1089b18d193
- Local pid:
-
pubs:638533
- Source identifiers:
-
638533
- Deposit date:
-
2016-11-03
Terms of use
- Copyright holder:
- Cantone et al
- Copyright date:
- 2016
- Notes:
- Author(s) retain copyright; published by Nature Publishing Group under a Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record