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Journal article

APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review

Abstract:

APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is considerable research interest in understanding whether APOE-ε4 influences cognition in healthy adults. Despite a substantial literature reporting effects of APOE genotype on cognition, findings are inconsistent. In particular, it is challenging to separate whether cognitive deficits in APOE-ε4 carriers reflect the influence of prodromal dementia pathology ("prodromal hypothesis"), or a direct contribu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cortex.2018.03.025

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Oxford college:
Linacre College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
ORCID:
0000-0001-8995-2099
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
Publisher:
Elsevier Publisher's website
Journal:
Cortex Journal website
Volume:
104
Pages:
103-123
Publication date:
2018-03-30
Acceptance date:
2018-03-19
DOI:
EISSN:
1973-8102
ISSN:
0010-9452
Pubs id:
pubs:854505
URN:
uri:a5779aa7-3076-434b-9576-f7350e23fab9
UUID:
uuid:a5779aa7-3076-434b-9576-f7350e23fab9
Local pid:
pubs:854505

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