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Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?

Abstract:

The Holliday junction (HJ) is a central intermediate of homologous recombination. Its cleavage is critical for the formation of crossover recombinants during meiosis, which in turn helps to establish chiasmata and promote genetic diversity. Enzymes that cleave HJs, called HJ resolvases, have been identified in all domains of life except eukaryotic nuclei. Controversially, the Mus81-Eme1 endonuclease has been proposed to be an example of a eukaryotic nuclear resolvase. However, hitherto little...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601645

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
Journal:
EMBO journal
Volume:
26
Issue:
7
Pages:
1891-1901
Publication date:
2007-04-01
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
Source identifiers:
11314

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