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Mus81 cleavage of Holliday junctions: a failsafe for processing meiotic recombination intermediates?

Abstract:

The Holliday junction (HJ) is a central intermediate of homologous recombination. Its cleavage is critical for the formation of crossover recombinants during meiosis, which in turn helps to establish chiasmata and promote genetic diversity. Enzymes that cleave HJs, called HJ resolvases, have been identified in all domains of life except eukaryotic nuclei. Controversially, the Mus81-Eme1 endonuclease has been proposed to be an example of a eukaryotic nuclear resolvase. However, hitherto little...

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Publication status:
Published

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Publisher copy:
10.1038/sj.emboj.7601645

Authors


Gaskell, LJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
The EMBO journal
Volume:
26
Issue:
7
Pages:
1891-1901
Publication date:
2007-04-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:a56a238a-eb9e-4160-9cf4-b33cb5e6f64d
Source identifiers:
11314
Local pid:
pubs:11314

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