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Journal article

The Brn-2 transcription factor links activated BRAF to melanoma proliferation.

Abstract:

Malignant melanoma, an aggressive and increasingly common cancer, is characterized by a strikingly high rate (70%) of mutations in BRAF, a key component of the mitogen-activated protein (MAP) kinase signaling pathway. How signaling events downstream from BRAF affect the underlying program of gene expression is poorly understood. We show that the Brn-2 POU domain transcription factor is highly expressed in melanoma cell lines but not in melanocytes or melanoblasts and that overexpression of Br...

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Publication status:
Published

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Authors


Goodall, J More by this author
Wellbrock, C More by this author
Dexter, TJ More by this author
Roberts, K More by this author
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Journal:
Molecular and cellular biology
Volume:
24
Issue:
7
Pages:
2923-2931
Publication date:
2004-04-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:a568842e-971a-4823-937e-1d95313af19e
Source identifiers:
92995
Local pid:
pubs:92995

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