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A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content.

Abstract:

OBJECTIVE: Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. METHODS AND RESULTS: In vivo magnetic resonance imaging in apolipoprotein E-deficient mice showed rapid binding of PV-MPIO to the aortic ro...

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Publication status:
Published

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Publisher copy:
10.1161/atvbaha.111.241844

Authors


McAteer, MA More by this author
Ruparelia, N More by this author
Jefferson, A More by this author
Nugent, HB More by this author
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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
32
Issue:
6
Pages:
1427-1435
Publication date:
2012-06-05
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
URN:
uuid:a55a874d-e49a-497a-be3b-ec9824d7b947
Source identifiers:
323080
Local pid:
pubs:323080

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