- Abstract:
-
OBJECTIVE: Endothelial cell activation is an important mediator of monocyte recruitment to sites of vascular inflammation. We hypothesized that high-affinity dual-ligand microparticles of iron oxide (MPIO), targeted to P-selectin and vascular cell adhesion molecule-1 (PV-MPIO), would identify activated endothelial cells during atherosclerosis progression. METHODS AND RESULTS: In vivo magnetic resonance imaging in apolipoprotein E-deficient mice showed rapid binding of PV-MPIO to the aortic ro...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1161/atvbaha.111.241844
-
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- Journal:
- Arteriosclerosis, thrombosis, and vascular biology
- Volume:
- 32
- Issue:
- 6
- Pages:
- 1427-1435
- Publication date:
- 2012-06-05
- DOI:
- EISSN:
-
1524-4636
- ISSN:
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1079-5642
- URN:
-
uuid:a55a874d-e49a-497a-be3b-ec9824d7b947
- Source identifiers:
-
323080
- Local pid:
- pubs:323080
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
A leukocyte-mimetic magnetic resonance imaging contrast agent homes rapidly to activated endothelium and tracks with atherosclerotic lesion macrophage content.
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