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Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS

Abstract:

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-related phenotypes can help to improve treatment options and drug development. Here we perform promoter Capture Hi-C in human adipocytes to investigate interactions between gene promoters and distal elements as a transcription-regulating mechanism contributing to these phenotypes. We find that promoter-interacting ele...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-018-03554-9

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Grant:
HL-095056
HL-28481
U01 DK105561
R00 HL121172
DK093757
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 1512
Publication date:
2018-04-17
Acceptance date:
2018-02-22
DOI:
ISSN:
2041-1723
Pubs id:
pubs:844669
URN:
uri:a53fb777-aaeb-47d5-9ff6-e8c4e94b1a92
UUID:
uuid:a53fb777-aaeb-47d5-9ff6-e8c4e94b1a92
Local pid:
pubs:844669
Language:
English

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