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Journal article

Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8alpha+ dendritic cells.

Abstract:

In mouse, a subset of dendritic cells (DCs) known as CD8alpha+ DCs has emerged as an important player in the regulation of T cell responses and a promising target in vaccination strategies. However, translation into clinical protocols has been hampered by the failure to identify CD8alpha+ DCs in humans. Here, we characterize a population of human DCs that expresses DNGR-1 (CLEC9A) and high levels of BDCA3 and resembles mouse CD8alpha+ DCs in phenotype and function. We describe the presence of...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20092618

Authors


Poulin, LF More by this author
Griessinger, E More by this author
Anjos-Afonso, F More by this author
Craciun, L More by this author
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Journal:
The Journal of experimental medicine
Volume:
207
Issue:
6
Pages:
1261-1271
Publication date:
2010-06-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:a53ef689-d20a-4797-bdd0-673de5a538f1
Source identifiers:
96031
Local pid:
pubs:96031

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