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Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology.

Abstract:

Congestive heart failure (CHF) is characterized by impaired cardiovascular reflexes and increased neurohumoral drive. The long-term sympatho-excitation increases the progression and risk of mortality during CHF. The paraventricular nucleus (PVN) of the hypothalamus is a very important central site for integration of sympathetic outflow and cardiovascular function. Within the PVN, nitric oxide (NO), mainly generated by neuronal nitric oxide synthase (nNOS), functions in inhibitory regulation o...

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine, BHF Centre of Research Excellence
Role:
Author
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Journal:
Methods in molecular medicine
Volume:
112
Pages:
59-79
Publication date:
2005-01-01
EISSN:
1940-6037
ISSN:
1543-1894
URN:
uuid:a53bd25e-0460-4796-867e-179c65857ac6
Source identifiers:
104849
Local pid:
pubs:104849

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