Journal article icon

Journal article

The ABC of APC.

Abstract:

Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease characterized by the presence of adenomatous polyps in the colon and rectum, with inevitable development of colorectal cancer if left untreated. FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Somatic mutations in the APC gene are an early event in colorectal tumorigenesis, and can be detected in the majority of colorectal tumours. The APC gene encodes a large protein with multipl...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1093/hmg/10.7.721

Authors


Journal:
Human molecular genetics
Volume:
10
Issue:
7
Pages:
721-733
Publication date:
2001-04-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:a52575f9-4da0-4a1c-a26c-e65407b69f46
Source identifiers:
178048
Local pid:
pubs:178048

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP