Human TLR-7-, -8-, and -9-mediated induction of IFN-alpha/beta and -lambda Is IRAK-4 dependent and redundant for protective immunity to viruses.

Journal article

Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-alpha/beta and -lambda. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-alpha/beta and -lambda induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-alpha/beta and -lambda were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-beta a...

Expand abstract

Authors: Yang, K; Puel, A; Zhang, S; Eidenschenk, C; Ku, C

• Publication status: Published
• Journal: Immunity
• Volume: 23
• Issue: 5
• Pages: 465-478
• Publication date: 2005-11-01
• DOI: 10.1016/j.immuni.2005.09.016
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Poly I-C; Toll-Like Receptors; Signal Transduction; Humans; Toll-Like Receptor 8; Virus Diseases; Gene Expression Regulation; Interferons; Toll-Like Receptor 9; Phosphotransferases (Alcohol Group Acceptor); Viruses; Fibroblasts; Interleukin-1 Receptor-Associated Kinases; Toll-Like Receptor 7