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Sonothrombolysis with magnetically targeted microbubbles

Abstract:

Microbubble-enhanced sonothrombolysis is a promising approach to increase the safety and efficacy of current pharmacological treatments for ischemic stroke. Maintaining therapeutic concentrations of microbubbles and drugs at the clot site however poses a challenge. The objective of this study was to investigate the efficacy of magnetic microbubble targeting upon clot lysis rates in vitro. Retracted whole porcine blood clots were placed in a flow phantom of a partially occluded middle cerebral...

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Department:
Engineering Science
Role:
Researcher, Creator
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Grant:
EP/G036861/1
Funding agency for:
Project
Publisher:
University of Oxford
Publication date:
2019
Data collected:
2015 - 2016
Language:
English
Format:
Digital
Documentation:
This data underpins the following paper: de Saint Victor et al., Sonothrombolysis with magnetically targeted microbubbles, Ultrasound in Medicine & Biology, 2019. There are 5 sections: 1) Magnetic field caracterisation: magnitude of the magnetic field and of the magnetic field gradient in the experimental setup (used in figure 2) 2) Accumulation of magnetic material in the focal region with and without a magnet (used in figure 3) 3) Lysis rates (used in figures 4 and 8) 4) Acoustic energy de... Expand documentation

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