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Alternative activation of macrophages: mechanism and functions.

Abstract:

The concept of an alternative pathway of macrophage activation has stimulated interest in its definition, mechanism, and functional significance in homeostasis and disease. We assess recent research in this field, argue for a restricted definition, and explore pathways by which the T helper 2 (Th2) cell cytokines interleukin-4 (IL-4) and IL-13 mediate their effects on macrophage cell biology, their biosynthesis, and responses to a normal and pathological microenvironment. The stage is now set...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Immunity
Volume:
32
Issue:
5
Pages:
593-604
Publication date:
2010-05-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Source identifiers:
58622
Language:
English
Keywords:
Pubs id:
pubs:58622
UUID:
uuid:a4ffeff3-d434-4bf3-84d5-0a70abc794c0
Local pid:
pubs:58622
Deposit date:
2012-12-19

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