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Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors.

Abstract:

Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine. In order to investigate structural mechanisms of resistance for different NNRTI classes we have determined six crystal structures of mutant RT-inhibitor complexes. Val108 does not have direct contact with nevirapine in wild-type RT and in the RT(Val108Ile) c...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2003.12.055

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Journal:
Journal of molecular biology
Volume:
336
Issue:
3
Pages:
569-578
Publication date:
2004-02-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:a4fe4f40-f18f-44c5-8b19-0f0aac01ff92
Source identifiers:
72616
Local pid:
pubs:72616

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