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2'-alkynylnucleotides: A sequence- and spin label-flexible strategy for EPR spectroscopy in DNA.

Abstract:

Electron paramagnetic resonance (EPR) spectroscopy is a powerful method to elucidate molecular structure through the measurement of distances between conformationally well-defined spin labels. Here we report a sequence-flexible approach to the synthesis of double spin-labeled DNA duplexes, where 2'-alkynylnucleosides are incorporated at terminal and internal positions on complementary strands. Post-DNA synthesis copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with a variety of s...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1021/jacs.6b05421

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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Author
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Author
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Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Author
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Grant:
University Research Fellowship
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Publisher:
American Chemical Society Publisher's website
Journal:
Journal of the American Chemical Society Journal website
Volume:
138
Issue:
29
Pages:
9069-9072
Publication date:
2016-07-05
Acceptance date:
2016-07-13
DOI:
ISSN:
1520-5126 and 0002-7863
Pubs id:
pubs:634545
URN:
uri:a4f848a7-01c5-45d6-b0a1-7b760de5e0d5
UUID:
uuid:a4f848a7-01c5-45d6-b0a1-7b760de5e0d5
Local pid:
pubs:634545
Language:
English
Keywords:

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