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Journal article

Prediction of susceptibility to first-line tuberculosis drugs by DNA sequencing

Abstract:

Background

The World Health Organization recommends drug-susceptibility testing of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment decisions and improve outcomes. Whether DNA sequencing can be used to accurately predict profiles of susceptibility to first-line antituberculosis drugs has not been clear.

Methods

We obtained whole-genome sequences and associated phenotypes of resistance or susceptibility to the first-line anti...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1056/NEJMoa1800474

Authors


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Institution:
University of Oxford
Division:
MPLS Division
Department:
Engineering Sciences
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
RDM Clinical Laboratory Science
Role:
Author
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NHS England More from this funder
Public Health England More from this funder
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Publisher:
Massachusetts Medical Society Publisher's website
Journal:
New England Journal of Medicine Journal website
Volume:
379
Issue:
15
Pages:
1403-1415
Publication date:
2018-10-11
Acceptance date:
2018-08-15
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Pubs id:
pubs:910678
URN:
uri:a4e5c655-51c0-46aa-9d68-cc276b003c70
UUID:
uuid:a4e5c655-51c0-46aa-9d68-cc276b003c70
Local pid:
pubs:910678

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