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Journal article

Polyfunctional T cell responses are a hallmark of HIV-2 infection.

Abstract:

HIV-2 is distinguished clinically and immunologically from HIV-1 infection by delayed disease progression and maintenance of HIV-specific CD4(+) T cell help in most infected subjects. Thus, HIV-2 provides a unique natural human model in which to investigate correlates of immune protection against HIV disease progression. Here, we report a detailed assessment of the HIV-2-specific CD4(+) and CD8(+) T cell response compared to HIV-1, using polychromatic flow cytometry to assess the quality of t...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200737768

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
European journal of immunology
Volume:
38
Issue:
2
Pages:
350-363
Publication date:
2008-02-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:a4d3789c-b3d7-44aa-95e0-6ae370f870f9
Source identifiers:
13575
Local pid:
pubs:13575

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