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The 'sticky business' of cleaning gas-phase membrane proteins: a detergent oriented perspective.

Abstract:

In recent years the properties of gas-phase detergent clusters have come under close scrutiny due in part to their participation in the analysis of intact membrane protein complexes by mass spectrometry. The detergent molecules that cover the protein complex are removed in the gas-phase by thermally agitating the ions by collision-induced dissociation. This process however, is not readily controlled and can frequently result in the disruption of protein structure. Improved methods of releasin...

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Publication status:
Published

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Publisher copy:
10.1039/c2cp41687e

Authors


Journal:
Physical chemistry chemical physics : PCCP
Volume:
14
Issue:
42
Pages:
14439-14449
Publication date:
2012-11-05
DOI:
EISSN:
1463-9084
ISSN:
1463-9076
URN:
uuid:a4d04983-286a-4b3a-aaea-22df2fa141fd
Source identifiers:
353945
Local pid:
pubs:353945

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