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Complex DNA damage induced by high-LET a-particles and protons triggers a specific cellular DNA damage response

Abstract:

Purpose

Complex DNA damage (CDD), where two or more DNA lesions are induced in close proximity, is a signature of ionising radiation (IR) that contributes significantly to cell killing due to the difficult nature of its repair. However the precise mechanism of recognition and processing of CDD in cellular DNA, where the DNA is wrapped around histone proteins to form chromatin, is currently unknown.

Methods and Materials

HeLa and oropharyngeal squamous cell carcino...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ijrobp.2017.11.012

Authors


Carter, RJ More by this author
Nickson, CM More by this author
Thompson, JM More by this author
Kacperek, AJ More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology; CRUK/MRC Ox Inst for Radiation Oncology
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North West Cancer Research More from this funder
Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology, Biology, Physics Journal website
Volume:
100
Issue:
3
Pages:
776–784
Publication date:
2017-11-13
Acceptance date:
2017-11-07
DOI:
Pubs id:
pubs:745899
URN:
uri:a4bfbde5-96b6-4795-b2fa-e677e92eed97
UUID:
uuid:a4bfbde5-96b6-4795-b2fa-e677e92eed97
Local pid:
pubs:745899

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