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Journal article

Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.

Abstract:

Base excision repair (BER) is a highly conserved DNA repair pathway throughout all kingdoms from bacteria to humans. Whereas several enzymes are required to complete the multistep repair process of damaged bases, apurinic-apyrimidic (AP) endonucleases play an essential role in enabling the repair process by recognizing intermediary abasic sites cleaving the phosphodiester backbone 5' to the abasic site. Despite extensive study, there is no structure of a bacterial AP endonuclease bound to sub...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1206563109

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
42
Pages:
16852-16857
Publication date:
2012-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:a4af6ced-7b26-4c3c-a3b6-ab9aab7fc20a
Source identifiers:
353988
Local pid:
pubs:353988

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