- Abstract:
-
Base excision repair (BER) is a highly conserved DNA repair pathway throughout all kingdoms from bacteria to humans. Whereas several enzymes are required to complete the multistep repair process of damaged bases, apurinic-apyrimidic (AP) endonucleases play an essential role in enabling the repair process by recognizing intermediary abasic sites cleaving the phosphodiester backbone 5' to the abasic site. Despite extensive study, there is no structure of a bacterial AP endonuclease bound to sub...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.1206563109
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 109
- Issue:
- 42
- Pages:
- 16852-16857
- Publication date:
- 2012-10-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:a4af6ced-7b26-4c3c-a3b6-ab9aab7fc20a
- Source identifiers:
-
353988
- Local pid:
- pubs:353988
- Copyright date:
- 2012
Journal article
Structural basis for the recognition and cleavage of abasic DNA in Neisseria meningitidis.
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