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The C-terminal priming domain is strongly associated with the main body of bacteriophage ϕ6 RNA-dependent RNA polymerase.

Abstract:

Double-stranded RNA viruses encode a single protein species containing RNA-dependent RNA polymerase (RdRP) motifs. This protein is responsible for RNA transcription and replication. The architecture of viral RdRPs resembles that of a cupped right hand with fingers, palm and thumb domains. Those using de novo initiation have a flexible structural elaboration that constitutes the priming platform. Here we investigate the properties of the C-terminal priming domain of bacteriophage ϕ6 to get ins...

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Publication status:
Published

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Publisher copy:
10.1016/j.virol.2012.05.035

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Virology
Volume:
432
Issue:
1
Pages:
184-193
Publication date:
2012-10-05
DOI:
EISSN:
1096-0341
ISSN:
0042-6822
URN:
uuid:a4aebb51-d77e-4c23-ae67-d14350a884bd
Source identifiers:
342872
Local pid:
pubs:342872

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