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The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis

Abstract:
MuSK myasthenia gravis is a rare, severe autoimmune disease of the neuromuscular junction, only identified in 2001, with unclear pathogenic mechanisms. In this review we describe the clinical aspects that distinguish MuSK MG from AChR MG, review what is known about the role of MuSK in the development and function of the neuromuscular junction, and discuss the data that address how the antibodies to MuSK lead to neuromuscular transmission failure. © 2013 Anatomical Society.

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Publisher copy:
10.1111/joa.12034

Authors


Koneczny, I More by this author
Cossins, J More by this author
Vincent, A More by this author
Journal:
Journal of Anatomy
Volume:
224
Issue:
1
Pages:
29-35
Publication date:
2014-01-05
DOI:
EISSN:
1469-7580
ISSN:
0021-8782
URN:
uuid:a49b52e1-214d-4c05-96bb-7cc358dcb949
Source identifiers:
444526
Local pid:
pubs:444526

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