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Journal article

Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis

Abstract:

BACKGROUND: C/EBPa and C/EBPb are transcription factors with tissue specific expression regulating several important cellular processes. They work by recruiting protein complexes to a common DNA recognition motif and both are able to compensate each other's absence in many cell types, thus showing functional redundancy. They also play distinct roles in specific cellular pathways and their abnormal functioning gives raise to different human pathologies. METHODS: To investigate the molecular ba...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.bbagen.2016.10.002

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Department:
Oxford, MSD, RDM, RDM Clinical Laboratory Sciences
Role:
Author
European Molecular Biology Laboratory More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Biochimica et Biophysica Acta (BBA) - General Subjects Journal website
Volume:
1861
Issue:
2
Pages:
467–476
Publication date:
2016-10-13
DOI:
ISSN:
0304-4165
Pubs id:
pubs:653454
URN:
uri:a47d5715-0984-49e4-907a-ae15f78914a6
UUID:
uuid:a47d5715-0984-49e4-907a-ae15f78914a6
Local pid:
pubs:653454
Paper number:
2

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