The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction.

Journal article

Before a sperm can fertilize an egg it must undergo a final activation step induced by the egg termed the acrosome reaction. During the acrosome reaction a lysosome-related organelle, the acrosome, fuses with the plasma membrane to release hydrolytic enzymes and expose an egg-binding protein. Because NAADP (nicotinic acid adenine dinucleotide phosphate) releases Ca(2+) from acidic lysosome-related organelles in other cell types, we investigated a possible role for NAADP in mediating the acros...

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Authors: Vasudevan, SR; Lewis, A; Chan, J; Machin, C; Sinha, D

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 285
• Issue: 24
• Pages: 18262-18269
• Publication date: 2010-06-01
• DOI: 10.1074/jbc.m109.087858
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Cations; Exocytosis; Acrosome Reaction; NADP; Acrosome; Fura-2; Animals; Female; Manganese; Protein Binding; Spermatozoa; Calcium; Sea Urchins; Signal Transduction; Male