Journal article icon

Journal article

Tyrosine dephosphorylation is required for Bak activation in apoptosis.

Abstract:

Activation of the cell-death mediator Bak commits a cell to mitochondrial apoptosis. The initial steps that govern Bak activation are poorly understood. To further clarify these pivotal events, we have investigated whether post-translational modifications of Bak impinge on its activation potential. In this study, we report that on apoptotic stimulation Bak undergoes dephosphorylation at tyrosine residue 108 (Y108), a critical event that is necessary but not sufficient for Bak activation, but ...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/emboj.2010.244

Authors


Ternette, N More by this author
Leverrier, S More by this author
Expand authors...
Journal:
The EMBO journal
Volume:
29
Issue:
22
Pages:
3853-3868
Publication date:
2010-11-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:a46febfa-63a8-4440-9a83-5f2dcd8f9d41
Source identifiers:
90795
Local pid:
pubs:90795

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP