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Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.

Abstract:

Type 1 11 beta-hydroxysteroid dehydrogenase constitutes a prereceptor control mechanism through its ability to reduce dehydroglucocorticoids to the receptor ligands cortisol and corticosterone in vivo. We compared kinetic characteristics of the human and guinea pig 11 beta-hydroxysteroid dehydrogenase isozymes derived from species differing in glucocorticoid sensitivity. Both orthologs were successfully expressed as full-length enzymes in yeast and COS7 cells and as soluble transmembrane-dele...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m210135200

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Journal:
The Journal of biological chemistry
Volume:
278
Issue:
3
Pages:
2030-2035
Publication date:
2003-01-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:a465fdaa-c3c9-41a2-abd1-08417b316bf3
Source identifiers:
108396
Local pid:
pubs:108396

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