- Abstract:
-
Type 1 11 beta-hydroxysteroid dehydrogenase constitutes a prereceptor control mechanism through its ability to reduce dehydroglucocorticoids to the receptor ligands cortisol and corticosterone in vivo. We compared kinetic characteristics of the human and guinea pig 11 beta-hydroxysteroid dehydrogenase isozymes derived from species differing in glucocorticoid sensitivity. Both orthologs were successfully expressed as full-length enzymes in yeast and COS7 cells and as soluble transmembrane-dele...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1074/jbc.m210135200
-
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- Journal:
- The Journal of biological chemistry
- Volume:
- 278
- Issue:
- 3
- Pages:
- 2030-2035
- Publication date:
- 2003-01-05
- DOI:
- EISSN:
-
1083-351X
- ISSN:
-
0021-9258
- URN:
-
uuid:a465fdaa-c3c9-41a2-abd1-08417b316bf3
- Source identifiers:
-
108396
- Local pid:
- pubs:108396
- Copyright date:
- 2003
Journal article
Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species.
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