Journal article
Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium mendelian randomization study
- Abstract:
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Background
C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.
Methods and Findings
We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the seco...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.3MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pmed.1001976
Authors
Bibliographic Details
- Publisher:
- PLoS Medicine
- Journal:
- PLoS Medicine More from this journal
- Volume:
- 13
- Issue:
- 6
- Pages:
- e1001976
- Publication date:
- 2016-06-21
- Acceptance date:
- 2016-02-03
- DOI:
- ISSN:
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1549-1277 and 1549-1676
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:630985
- UUID:
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uuid:a460308e-db54-4273-a8cf-ad32e56f439a
- Local pid:
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pubs:630985
- Source identifiers:
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630985
- Deposit date:
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2016-08-24
Terms of use
- Copyright holder:
- Prins et al
- Copyright date:
- 2016
- Notes:
- © 2016 Prins et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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