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Investigating the causal relationship of c-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium mendelian randomization study

Abstract:

Background

C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal.

Methods and Findings

We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene (GRSCRP), and the seco...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pmed.1001976

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Publisher:
PLoS Medicine Publisher's website
Journal:
PLoS Medicine Journal website
Volume:
13
Issue:
6
Pages:
e1001976
Publication date:
2016-06-21
Acceptance date:
2016-02-03
DOI:
ISSN:
1549-1676 and 1549-1277
Pubs id:
pubs:630985
URN:
uri:a460308e-db54-4273-a8cf-ad32e56f439a
UUID:
a460308e-db54-4273-a8cf-ad32e56f439a
Local pid:
pubs:630985
Language:
English
Keywords:

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