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Regulation of type II transmembrane serine proteinase TMPRSS6 by hypoxia-inducible factors: new link between hypoxia signaling and iron homeostasis.

Abstract:

Hepcidin is a liver-derived hormone with a key role in iron homeostasis. In addition to iron, it is regulated by inflammation and hypoxia, although mechanisms of hypoxic regulation remain unclear. In hepatocytes, hepcidin is induced by bone morphogenetic proteins (BMPs) through a receptor complex requiring hemojuvelin (HJV) as a co-receptor. Type II transmembrane serine proteinase (TMPRSS6) antagonizes hepcidin induction by BMPs by cleaving HJV from the cell membrane. Inactivating mutations i...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.173096

Authors


Schödel, J More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, BHF Centre of Research Excellence
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
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Journal:
The Journal of biological chemistry
Volume:
286
Issue:
6
Pages:
4090-4097
Publication date:
2011-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:a45d0277-12c9-424c-b012-03ea8c8519e6
Source identifiers:
90801
Local pid:
pubs:90801

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