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An acoustic microscopy technique to assess particle size and distribution following needle-free injection.

Abstract:

Needle-free injection is a novel technique for transdermal drug and vaccine delivery, the efficacy of which depends on the number density and mean penetration depth of particles beneath the skin. To date, these parameters have been assessed optically, which is time-consuming and unsuitable for use in vivo. The present work describes the development of a scanning acoustic microscopy technique to map and size particle distributions following injection. Drug particles were modeled using a polydi...

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Publication status:
Published

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Publisher copy:
10.1121/1.3314252

Authors


Condliffe, J More by this author
Schiffter, HA More by this author
Cleveland, RO More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Engineering Science
Journal:
The Journal of the Acoustical Society of America
Volume:
127
Issue:
4
Pages:
2252-2261
Publication date:
2010-04-05
DOI:
EISSN:
1520-8524
ISSN:
0001-4966
URN:
uuid:a455c4e6-9043-42b1-9317-122b91a8793a
Source identifiers:
62625
Local pid:
pubs:62625

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